SLU-PP-332 5mg

It is critical to understand that SLU-PP-332 is a research chemical that has not been approved for human use by the FDA or any other regulatory body. All of the data on its effects and safety comes from preclinical studies in animals, primarily mice. There have been no human clinical trials conducted with this substance. As a reminder, the terms of use clearly state these are research chemicals and not allowed to be used for human consumption.

Potential Risks Identified in Preclinical Studies

• Hepatotoxicity: High doses of SLU-PP-332 (≥100 mg/kg in mice) have been associated with elevated levels of liver enzymes (ALT/AST), indicating potential liver damage.

• Cardiac Hypertrophy: SLU-PP-332 is a "pan-agonist," meaning it activates all three estrogen-related receptors (ERRα, ERRβ, and ERRγ). While ERRα is the intended target for its metabolic effects, activation of ERRγ has been shown to cause cardiac hypertrophy (enlargement of the heart) in mice.
• Nutrient Exhaustion: Chronic administration (e.g., 12 weeks in mice) has been shown to deplete muscle glycogen reserves. This suggests that the continuous "exercise-mimicking" effect of the drug could lead to a state of nutrient exhaustion, which may require careful management.
• Off-Target Effects: The pan-agonist nature of SLU-PP-332 means it can have effects on ERRβ and ERRγ in addition to the primary target, ERRα. This raises concerns about unforeseen or off-target toxicity.
• Unknown Long-Term Effects: Since there have been no human studies, the long-term effects of using SLU-PP-332 are completely unknown.

General Risks Associated with Unregulated Research Chemicals

• Contamination and Purity: Because this chemical is not regulated for human use, there is no guarantee of its purity or sterility. It could be contaminated with other substances, or the stated concentration may be inaccurate.

• Lack of Safety Data: There is a complete absence of human clinical data regarding pharmacokinetics (how the body absorbs, distributes, metabolizes, and excretes the drug), and there is no information on potential side effects in humans.

• Lack of Medical Supervision: Use of such a substance would be without medical supervision, which is highly dangerous given the potential for serious side effects and the lack of a protocol for managing them.

• Uncertainty of Dosage: Dosages and administration protocols are based on animal studies and are not clinically validated for humans, making a safe dose impossible to determine.

• Potential for Legal Consequences: The possession and use of unapproved substances can have legal repercussions.

• Athletic Bans: Substances that mimic the effects of exercise are highly likely to be on the WADA Prohibited List, which would result in an athletic ban.